Methaqualone

Ah, my good friend Ludovico, the 'Lude! Top tier when fresh but lethal when stale; would recommend for time travelers ONLY. Many pharmaceutical binders break down over time whilst the active ingredients remain potent, meaning that a lot of medications are more quickly metabolized in your body if you eat them after the thing officially expires (as it's only the timed-release controlling agent that expired), leading to rapid overdose. This is the case for both Quaaludes and many barbiturates. Stay safe, my friends.